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Amoxicillin Dosage

Medically reviewed by Drugs.com. Last updated on Nov 30, 2023.

Applies to the following strengths: 250 mg; 500 mg; 125 mg/5 mL; 50 mg/mL; 250 mg/5 mL; 125 mg; 200 mg; 400 mg; 875 mg; 200 mg/5 mL; 400 mg/5 mL; 600 mg; 775 mg

Usual Adult Dose for Bacterial Endocarditis Prophylaxis

American Heart Association (AHA) recommendations:


Comments:

Usual Adult Dose for Chlamydia Infection

US CDC recommendations: 500 mg orally 3 times a day for 7 days in pregnant patients as an alternative to azithromycin

Comments:

Usual Adult Dose for Helicobacter pylori Infection

Immediate-release:


Comments: Refer to clarithromycin and lansoprazole for full prescribing information.

Usual Adult Dose for Lyme Disease - Arthritis

Infectious Diseases Society of America (IDSA) recommendations: 500 mg orally 3 times a day for 14 to 28 days

Comments:

Usual Adult Dose for Lyme Disease - Carditis

Infectious Diseases Society of America (IDSA) recommendations: 500 mg orally 3 times a day for 14 to 28 days

Comments:

Usual Adult Dose for Lyme Disease - Erythema Chronicum Migrans

Infectious Diseases Society of America (IDSA) recommendations: 500 mg orally 3 times a day for 14 to 28 days

Comments:

Usual Adult Dose for Lyme Disease

Infectious Diseases Society of America (IDSA) recommendations: 500 mg orally 3 times a day for 14 to 28 days

Comments:

Usual Adult Dose for Pneumonia

Immediate-release:


Use: For the treatment of infections of the lower respiratory tract due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

IDSA and American Thoracic Society (ATS) recommendations:
Pneumonia:

Comments:

Use: For outpatient empirical treatment of community-acquired pneumonia

Usual Adult Dose for Bronchitis

Immediate-release:


Use: For the treatment of infections of the lower respiratory tract due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

IDSA and American Thoracic Society (ATS) recommendations:
Pneumonia:

Comments:

Use: For outpatient empirical treatment of community-acquired pneumonia

Usual Adult Dose for Sinusitis

Immediate-release:


Comments: Dosing for infections caused by bacteria that are intermediate in their susceptibility should follow recommendations for severe infections.

Uses: For the treatment of infections of the ear, nose and throat due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) Streptococcus pneumoniae, Staphylococcus species, or Haemophilus influenzae; for the treatment of infections of the genitourinary tract due to susceptible (only beta lactamase negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis; and for the treatment of infections of the skin and structure due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

Usual Adult Dose for Urinary Tract Infection

Immediate-release:


Comments: Dosing for infections caused by bacteria that are intermediate in their susceptibility should follow recommendations for severe infections.

Uses: For the treatment of infections of the ear, nose and throat due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) Streptococcus pneumoniae, Staphylococcus species, or Haemophilus influenzae; for the treatment of infections of the genitourinary tract due to susceptible (only beta lactamase negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis; and for the treatment of infections of the skin and structure due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

Usual Adult Dose for Tonsillitis/Pharyngitis

Extended-release: 775 mg orally once a day within 1 hour after a meal for 10 days

Comments: The full 10-day course of treatment should be completed in order to be effective.

Uses: For the treatment of tonsillitis and/or pharyngitis secondary to Streptococcus pyogenes

IDSA recommendations:
Immediate-release: 1000 mg orally once a day or 500 mg orally twice a day

Use: For the treatment of Group A Streptococcal pharyngitis

Usual Adult Dose for Skin and Structure Infection

Immediate-release:


Comments: Dosing for infections caused by bacteria that are intermediate in their susceptibility should follow recommendations for severe infections.

Use: For the treatment of infections of the skin and structure due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

IDSA recommendations:

Use: For the treatment of erysipeloid

Usual Adult Dose for Cutaneous Bacillus anthracis

US CDC Recommendations: 1 g orally every 8 hours
Duration of prophylaxis: 60 days

Comments:

Usual Adult Dose for Anthrax Prophylaxis

US CDC Recommendations: 1 g orally every 8 hours
Duration of prophylaxis: 60 days

Comments:

Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis

AHA recommendations:
Children:


Comments:

Usual Pediatric Dose for Sinusitis

Immediate-Release Formulations:
Mild, Moderate, or Severe Infection:
3 months or younger: Up to 30 mg/kg/day orally in divided doses every 12 hours

Comments:


Immediate-Release Formulations:
Mild to Moderate Infection:
4 months or older:

Severe Infection:
4 months or older:

Comments: Dosing for infections caused by bacteria that are intermediate in their susceptibility should follow recommendations for severe infections.

Uses: For the treatment of infections of the ear, nose and throat due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) Streptococcus pneumoniae, Staphylococcus species, or Haemophilus influenzae; for the treatment of infections of the genitourinary tract due to susceptible (only beta lactamase negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis; and for the treatment of infections of the skin and structure due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

Usual Pediatric Dose for Skin or Soft Tissue Infection

Immediate-Release Formulations:
Mild, Moderate, or Severe Infection:
3 months or younger: Up to 30 mg/kg/day orally in divided doses every 12 hours

Comments:


Immediate-Release Formulations:
Mild to Moderate Infection:
4 months or older:

Severe Infection:
4 months or older:

Comments: Dosing for infections caused by bacteria that are intermediate in their susceptibility should follow recommendations for severe infections.

Uses: For the treatment of infections of the ear, nose and throat due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) Streptococcus pneumoniae, Staphylococcus species, or Haemophilus influenzae; for the treatment of infections of the genitourinary tract due to susceptible (only beta lactamase negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis; and for the treatment of infections of the skin and structure due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

Usual Pediatric Dose for Urinary Tract Infection

Immediate-Release Formulations:
Mild, Moderate, or Severe Infection:
3 months or younger: Up to 30 mg/kg/day orally in divided doses every 12 hours

Comments:


Immediate-Release Formulations:
Mild to Moderate Infection:
4 months or older:

Severe Infection:
4 months or older:

Comments: Dosing for infections caused by bacteria that are intermediate in their susceptibility should follow recommendations for severe infections.

Uses: For the treatment of infections of the ear, nose and throat due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) Streptococcus pneumoniae, Staphylococcus species, or Haemophilus influenzae; for the treatment of infections of the genitourinary tract due to susceptible (only beta lactamase negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis; and for the treatment of infections of the skin and structure due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

Usual Pediatric Dose for Pneumonia

Immediate-Release Formulations:
Mild, Moderate, or Severe infection:
3 months or younger: Up to 30 mg/kg/day orally in divided doses every 12 hours
4 months or older:


Use: For the treatment of infections of the lower respiratory tract due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

IDSA and the Pediatric Infectious Diseases Society recommendations:
Immediate-release formulations:
4 months or older:

Comments: Current guidelines should be consulted for additional information.

Use: For the management of community-acquired pneumonia

Usual Pediatric Dose for Bronchitis

Immediate-Release Formulations:
Mild, Moderate, or Severe infection:
3 months or younger: Up to 30 mg/kg/day orally in divided doses every 12 hours
4 months or older:


Use: For the treatment of infections of the lower respiratory tract due to susceptible (only beta lactamase negative) isolates of Streptococcus species (alpha and beta-hemolytic isolates only) S pneumoniae, Staphylococcus species, and H influenzae

IDSA and the Pediatric Infectious Diseases Society recommendations:
Immediate-release formulations:
4 months or older:

Comments: Current guidelines should be consulted for additional information.

Use: For the management of community-acquired pneumonia

Usual Pediatric Dose for Tonsillitis/Pharyngitis

12 years or older:


Comments: The full 10-day course of treatment should be completed in order to be effective.

Uses: For the treatment of tonsillitis and/or pharyngitis secondary to S pyogenes

IDSA recommendations:
Immediate-release: 50 mg/kg (maximum 1000 mg) orally once a day or 25 mg/kg (maximum 500 mg) twice a day

Use: For the treatment of Group A Streptococcal pharyngitis

Usual Pediatric Dose for Lyme Disease

IDSA recommendations:
Children:


Comments:

Usual Pediatric Dose for Otitis Media

American Academy of Pediatrics (AAP) and American Academy of Family Physicians (AAFP) recommendations:


Comments:

Use: For the treatment of acute otitis media

Usual Pediatric Dose for Inhalation Bacillus anthracis

AAP Recommendations:
Up to 1 week of age:


1 to 4 weeks:

1 month or older: 75 mg/kg/day orally in divided doses every 8 hours; not to exceed 1 g/dose

Duration of Therapy:
Postexposure prophylaxis for B anthracis infection: 60 days after exposure

Cutaneous anthrax without systemic involvement:

Follow-up for severe anthrax:

Comments:

Usual Pediatric Dose for Cutaneous Bacillus anthracis

AAP Recommendations:
Up to 1 week of age:


1 to 4 weeks:

1 month or older: 75 mg/kg/day orally in divided doses every 8 hours; not to exceed 1 g/dose

Duration of Therapy:
Postexposure prophylaxis for B anthracis infection: 60 days after exposure

Cutaneous anthrax without systemic involvement:

Follow-up for severe anthrax:

Comments:

Usual Pediatric Dose for Anthrax Prophylaxis

AAP Recommendations:
Up to 1 week of age:


1 to 4 weeks:

1 month or older: 75 mg/kg/day orally in divided doses every 8 hours; not to exceed 1 g/dose

Duration of Therapy:
Postexposure prophylaxis for B anthracis infection: 60 days after exposure

Cutaneous anthrax without systemic involvement:

Follow-up for severe anthrax:

Comments:

Renal Dose Adjustments

Extended-release Tablets:


Immediate-release formulations:
Mild to moderate renal dysfunction: No adjustment recommended.
Severe renal dysfunction:

Comments: Patients with severe renal dysfunction (CrCl less than 30 mL/min) should not receive the 875 mg tablets.

Liver Dose Adjustments

Data not available

Precautions

Extended-release tablets: Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis:

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

General:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.